{"id":2233,"date":"2021-11-16T11:11:53","date_gmt":"2021-11-16T03:11:53","guid":{"rendered":"http:\/\/hyqx.yo-l.com\/?page_id=2233"},"modified":"2022-03-26T14:34:07","modified_gmt":"2022-03-26T06:34:07","slug":"%e6%8a%80%e6%9c%af%e5%8e%9f%e7%90%86-%e5%88%bb%e6%af%8b%e9%99%90","status":"publish","type":"page","link":"https:\/\/www.hongyunqingxiao.com\/?page_id=2233","title":{"rendered":"\u6280\u672f\u539f\u7406-\u523b\u6bcb\u9650"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

<\/h2>

\u6280\u672f\u539f\u7406<\/span> \/ Technical Principles<\/span><\/h3><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\r\n\r\n
\r\n\r\n
\r\n \r\n \r\n
\r\n
\r\n
\r\n
\r\n \r\n
\r\n\r\n
\r\n\r\n \r\n \r\n \u9510\u6e43\u5c14 <\/span>\r\n \r\n \r\n\r\n \t<\/path>\t<\/path><\/g><\/svg>\r\n <\/span>\r\n \r\n <\/div>\r\n\r\n \r\n <\/div>\r\n <\/a>\r\n <\/div>\r\n
\r\n \r\n
\r\n\r\n
\r\n\r\n \r\n \r\n \u523b\u6bcb\u9650 <\/span>\r\n \r\n \r\n\r\n \t<\/path>\t<\/path><\/g><\/svg>\r\n <\/span>\r\n \r\n <\/div>\r\n\r\n \r\n <\/div>\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n \r\n
\r\n
\r\n
\r\n
\r\n \t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u521b\u65b0\u6027\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u2014\u9510\u6e43\u5c14<\/span>\u00ae<\/b><\/span><\/p>

\uff08REPERE\uff09\u00ae<\/span><\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u9510\u6e43\u5c14<\/span><\/b><\/span>\u00ae<\/sup><\/strong><\/span><\/b>\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5e94\u7528\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u9006\u8f6c\u5ea7\u5b50\uff08<\/span>Alu<\/span>\u5143\u4ef6\u53ca<\/span>LINE-1<\/span>\u8f6c\u5ea7\u5b50\uff09\u3001\u4eba\u6e90\u6838\u9178\u5185\u5207\u9176\u4ee5\u53ca\u9006\u8f6c\u5f55\u9176<\/span>ORF2p<\/span>\uff0c\u6574\u4e2a\u6280\u672f\u5b8c\u5168\u4e3a\u4eba\u6e90\uff0c\u56e0\u6b64\u5177\u6709\u4f4e\u514d\u75ab\u539f\u6027\u7684\u7279\u70b9\u3002<\/span><\/span><\/p>

\u9510\u6e43\u5c14<\/span><\/b>\u57fa\u00ae<\/sup>\u56e0\u7f16\u8f91\u6280\u672f\u9996\u5148\u8f6c\u5f55\u51fa\u542b\u6709\u9776\u4f4d\u70b9\u4e0a\u4e0b\u6e38\u5e8f\u5217\u53ca\u5f85\u63d2\u5165\u5e8f\u5217\u5e76\u8fde\u63a5\u7ecf\u6539\u9020\u7684\u9006\u8f6c\u5ea7\u5b50\u5e8f\u5217\u7684<\/span>RNA<\/span>\uff0c\u8be5<\/span>RNA<\/span>\u7ed3\u5408\u4eba\u6e90<\/span>ORF2p<\/span>\u540e\u8bc6\u522b\u57fa\u56e0\u7ec4\u4e0a\u7279\u5b9a\u4f4d\u70b9\uff08\u201cTTAAAA\u201d\uff09\u3001\u5207\u5f00\u57fa\u56e0\u7ec4\u5355\u94fe\u5e76\u4ee5\u6b64\u4e3a\u5f15\u7269\u5c06<\/span>RNA<\/span>\u9006\u8f6c\u5f55\u4e3a\u5355\u94fe<\/span>DNA<\/span>\u3002<\/span><\/span><\/p>

\u6b64\u540e\uff0c\u6240\u4ea7\u751f\u7684\u5355\u94fe<\/span>DNA<\/span>\u57fa\u4e8e\u5e8f\u5217\u7279\u5f02\u6027\u4e92\u8865\u7ed3\u5408\u4e8e\u57fa\u56e0\u7ec4\u4e0a\u9776\u4f4d\u70b9\u5904\uff0c\u7ed3\u5408\u4e8e\u5355\u94fe<\/span>DNA<\/span>\u7684<\/span>3′<\/span>\u7aef\u4e0a\u7684<\/span>ORF2p<\/span>\u53ef\u8bc6\u522b\u57fa\u56e0\u7ec4\u4e0a\u9776\u4f4d\u70b9\u4e0a\u6e38\u7684\u957f\u5e8f\u5217\uff0c\u5f53\u4e14\u4ec5\u5f53\u6240\u4ea7\u751f\u5355\u94fe<\/span>DNA<\/span>\u7684\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u4e0e\u57fa\u56e0\u7ec4\u4e0a\u7684\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u5b8c\u5168\u5339\u914d\u65f6\uff0c\u6839\u636eORF2p\u672c\u8eab\u805a\u5408\u9176\u7684\u4f5c\u7528\u6027\u8d28\uff0c\u65b9\u53ef\u4f7f<\/span>ORF2p<\/span>\u987a\u5229\u6ed1\u52a8\u81f3\u57fa\u56e0\u7ec4\u4e0a\u7684\u9776\u4f4d\u70b9\u5904\uff0c\u526a\u5207\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u7684<\/span>DNA<\/span>\u5355\u94fe\uff0c\u5e76\u4ee5\u6b64\u4e3a\u5f15\u7269\u5c06\u6b64\u524d\u4ea7\u751f\u7684\u5355\u94fe<\/span>DNA<\/span>\u8f6c\u5316\u4e3a\u53cc\u94fe<\/span>DNA<\/span>\u3002<\/span><\/span><\/p>

\u7ed3\u5408\u4e8e\u6240\u4ea7\u751f\u53cc\u94fe<\/span>DNA<\/span>\u7684<\/span>ORF2p<\/span>\u5728\u7ec6\u80de\u5206\u88c2\u671f\u518d\u6b21\u4f9d\u4e0a\u8ff0\u673a\u5236\u5207\u5f00\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u5355\u94fe\u7684\u540c\u65f6\uff0c\u5207\u5f00\u6240\u4ea7\u751f\u53cc\u94fe<\/span>DNA<\/span>\u7684\u76f8\u5e94\u5355\u94fe\u7684\u76f8\u5e94\u4f4d\u7f6e\uff0c\u4fc3\u8fdb\u5206\u88c2\u671f\u540c\u6e90\u91cd\u7ec4\u7684\u53d1\u751f\uff0c\u6700\u7ec8\u7ecf\u6548\u7387\u63d0\u9ad8\u7684\u540c\u6e90\u91cd\u7ec4\u5c06\u5f85\u63d2\u5165\u5e8f\u5217\u63d2\u5165\u81f3\u57fa\u56e0\u7ec4\u4e0a\u7684\u9776\u4f4d\u70b9\u5904\u3002<\/span><\/span><\/p>

\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b>\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7531\u4e8e\u4ec5\u5728\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u5904\u5f62\u6210\u53cc\u94fe<\/span>DNA<\/span>\u3001\u8bc6\u522b\u5e8f\u5217\u957f\u4ee5\u53ca\u5b8c\u5168\u4e3a\u4eba\u6e90\u7b49\u7279\u70b9\uff0c\u4f7f\u5f97\u5176\u5177\u6709\u9ad8\u9776\u5411\u6027\u3001\u4f4e\u8131\u9776\u7387\u53ca\u6781\u4f4e\u514d\u75ab\u539f\u6027\u7b49\u4f18\u52bf\uff0c\u5e76\u53ef\u4ee5\u8f83\u9ad8\u6548\u7387\u5411\u57fa\u56e0\u7ec4\u63d2\u5165\u957f\u7247\u6bb5\u5e8f\u5217\u3002\u540c\u65f6\uff0c\u8be5\u6280\u672f\u6240\u91c7\u7528\u7684\u4eba\u6e90\u6838\u9178\u5185\u5207\u9176<\/span>ORF2p<\/span>\u4ec5\u5207\u5f00\u57fa\u56e0\u7ec4\u5355\u94fe\uff0c\u6b64\u540e\u901a\u8fc7\u6548\u7387\u63d0\u9ad8\u7684\u540c\u6e90\u91cd\u7ec4\u8fdb\u884c\u5e8f\u5217\u63d2\u5165\uff0c\u6781\u5927\u7684\u907f\u514d\u4e86\u4f7f\u57fa\u56e0\u7ec4\u53d1\u751f\u53cc\u94fe\u65ad\u88c2\u7684\u98ce\u9669\uff0c\u56e0\u6b64\u5177\u6709\u8f83\u9ad8\u7684\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>

\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b>\u6280\u672f\u57fa\u56e0\u7f16\u8f91\u8fc7\u7a0b\u7b80\u8ff0<\/strong><\/span><\/p>

\u542b\u6709\u5f85\u63d2\u5165\u5e8f\u5217\u3001\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u53ca\u9776\u4f4d\u70b9\u4e0b\u6e38\u5e8f\u5217\u4fe1\u606f\u7684RNA\u88ab\u7531\u4e0e\u5176\u76f8\u8fde\u7684\u91cd\u590d\u5143\u4ef6\u53ca\u5176\u6240\u5f62\u6210\u7684\u7279\u5b9a\u4e8c\u7ea7\u7ed3\u6784\u6240\u62db\u52df\u7684\u5185\u5207\u9176\u53ca\u9006\u8f6c\u5f55\u9176ORF2p\u9006\u8f6c\u5f55\u8f6c\u5316\u4e3assDNA\u3002\u6b64\u540e\u8be5\u542b\u6709\u5f85\u63d2\u5165\u5e8f\u5217\u3001\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u53ca\u9776\u4f4d\u70b9\u4e0b\u6e38\u5e8f\u5217\u4fe1\u606f\u7684ssDNA\u4ee5\u5e8f\u5217\u7279\u5f02\u6027\u7ed3\u5408\u4e8e\u57fa\u56e0\u7ec4\u4e0a\u9776\u4f4d\u70b9\u5904\uff0c\u8fde\u4e8essDNA\u76843’\u7aef\u7684ORF2p\u5728ssDNA\u4e0a\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u4e0e\u57fa\u56e0\u7ec4\u4e0a\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u51c6\u786e\u5339\u914d\u540e\u65b9\u53ef\u6ed1\u52a8\u81f3\u9776\u4f4d\u70b9\uff08\u8be5\u673a\u5236\u4f7f\u5f97\u9510\u6e43\u5c14\u2122\u6280\u672f\u5177\u6709\u9ad8\u9776\u5411\u6027\u7684\u7279\u70b9\uff09\uff0c\u5728ssDNA\u5728\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u5904\u5f62\u6210\u7279\u5b9a\u201c\u03a9\u201d\u4e8c\u7ea7\u7ed3\u6784\u7684\u6761\u4ef6\u4e0b\uff0cORF2p\u5207\u5f00\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u5e76\u4ee5\u57fa\u56e0\u7ec4\u5355\u94fe\u4e3a\u5f15\u7269\u5408\u6210ssDNA\u7684\u53e6\u4e00\u6761\u94fe\uff0c\u8f6c\u53d8\u4e3adsDNA\u3002\u6b63\u56e0\u4ec5\u5728\u57fa\u56e0\u7ec4\u9776\u4f4d\u70b9\u5904\u65b9\u53ef\u5f62\u6210\u5177\u6709\u540c\u6e90\u91cd\u7ec4\u6f5c\u80fd\u7684dsDNA\uff0c\u4e14\u4e0d\u4ea7\u751f\u53cc\u94fe\u65ad\u88c2\uff0c\u9510\u6e43\u5c14\u2122\u6280\u672f\u624d\u66f4\u4e3a\u5b89\u5168\u3002\u6b64\u540e\u5728ORF2p\u7684\u8f85\u52a9\u4e0b\uff0cdsDNA\u4e0a\u7684\u5f85\u63d2\u5165\u5e8f\u5217\u53ef\u4e8e\u7ec6\u80de\u5206\u88c2\u65f6\u501f\u52a9\u540c\u6e90\u91cd\u7ec4\u88ab\u63d2\u5165\u81f3\u9776\u4f4d\u70b9\u4e2d\uff0c\u8fdb\u800c\u8fbe\u5230\u57fa\u56e0\u7f16\u8f91\u7684\u76ee\u7684\u3002\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b>\u6280\u672f\u6240\u7528\u5e8f\u5217\u548c\u86cb\u767d\u5747\u53d6\u81ea\u4eba\u4f53\uff0c\u4e3a\u5b8c\u5168\u4eba\u6e90\u7684\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u65e0\u9700\u62c5\u5fc3\u514d\u75ab\u53cd\u5e94\uff1b\u4e14\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b>\u6280\u672f\u57fa\u4e8e\u4eba\u4f53\u56fa\u6709\u7684\u57fa\u56e0\u53d8\u5316\u673a\u5236\u201cCNV\u5ef6\u4f38\u673a\u5236\u201d\uff0c\u5b89\u5168\u6027\u66f4\u6709\u4fdd\u969c\u3002<\/span><\/p>

<\/span><\/p>

\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b><\/span>\u7684\u6280\u672f\u5e94\u7528\u7279\u5f81<\/strong><\/span>
\u9510\u6e43\u5c14\u00ae<\/sup><\/span><\/b>\u53ef\u901a\u8fc7DNA\u3001RNA\uff08\u5305\u62ec\u4f53\u5916\u8f6c\u5f55\u65b9\u5f0f\uff09\u6216RNP\u591a\u79cd\u5f62\u5f0f\u4ecb\u5bfc\u57fa\u56e0\u7f16\u8f91\uff0c\u5177\u6709\u8f83\u9ad8\u7684\u4e34\u5e8a\u5e94\u7528\u6f5c\u80fd\u53ca\u4e34\u5e8a\u4ef7\u503c\u3002<\/span><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"16-img\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"07-bg\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

\u9510\u6e43\u5c14\u00ae\u7814\u53d1\u7ecf\u5386<\/h2><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t
\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n <\/span>\n\n \n
\n
\n 2021\u5e741\u670822\u65e5<\/span>\n <\/h5>\n
\n

\u9510\u6e43\u5c14\u2122\u6280\u672f\u7533\u8bf7\u53d1\u660e\u4e13\u5229<\/p> <\/div>\n <\/div>\n <\/div>\n \t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n <\/span>\n\n \n
\n
\n 2021\u5e742\u670811\u65e5<\/span>\n <\/h5>\n
\n

\u9510\u6e43\u5c14\u2122\u6280\u672f\u7684\u57fa\u672c\u7406\u8bba\u201cCNV\u5ef6\u4f38\u673a\u5236\u201d\u53d1\u8868\u4e8e\u201cfrontiers in Cell and Developmental Biology\u201d\uff08\u76ee\u524dIF\uff1a6.684\uff09<\/p> <\/div>\n <\/div>\n <\/div>\n \t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n <\/span>\n\n \n
\n
\n .<\/span>\n <\/h5>\n
\n

CNV\u5ef6\u4f38\u7406\u8bba\u5408\u7406\u7684\u89e3\u91ca\u4e86\u57fa\u56e0\u7ec4\u4e0a\u5e7f\u6cdb\u5b58\u5728\u7684\u5185\u542b\u5b50\u3001\u77ed\u6563\u5728\u6838\u5143\u4ef6\u548c\u957f\u6563\u5728\u6838\u5143\u4ef6\u7684\u5b58\u5728\u610f\u4e49\uff1b
\u540c\u65f6\u5bf9\u57fa\u56e0\u7ec4\u4e0a\u4e00\u7cfb\u5217\u673a\u5236\u5c1a\u4e0d\u660e\u6717\u7684\u53d8\u5316\u73b0\u8c61\u5982\u80da\u80ce\u548c\u80bf\u7624\u4e2d\u4e0e\u76f8\u5e94\u57fa\u56e0\u8868\u8fbe\u76f8\u5173\u7684\u62f7\u8d1d\u6570\u53d8\u5316\u3001\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u53ca\u8106\u6027X\u7efc\u5408\u75c7\u4e2d\u4e0e\u76f8\u5e94\u57fa\u56e0\u8868\u8fbe\u76f8\u5173\u7684\u4e09\u8054\u6838\u82f7\u9178\u91cd\u590d\u589e\u52a0\u53ca\u4ec5\u5728\u5177\u6709\u589e\u6b96\u6f5c\u80fd\u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u51fa\u73b0\u7684\u4e0d\u5b8c\u6574HIV\u57fa\u56e0\u7ec4\u5bf9\u9ad8\u8868\u8fbe\u57fa\u56e0\u4e2dAlu\u5e8f\u5217\u7684\u504f\u597d\u6027\u63d2\u5165\u7b49\u63d0\u51fa\u4e86\u66f4\u4e3a\u5408\u7406\u7684\u89e3\u91ca<\/p> <\/div>\n <\/div>\n <\/div>\n \t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n <\/span>\n\n \n
\n
\n 2021\u5e7412\u67081\u65e5<\/span>\n <\/h5>\n
\n

\u9510\u6e43\u5c14\u2122\u6280\u672f\u7533\u8bf7PCT\uff08\u56fd\u9645\u4e13\u5229\u7533\u8bf7\uff09<\/p> <\/div>\n <\/div>\n <\/div>\n \t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t

\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n <\/span>\n\n \n
\n
\n 2022\u5e743\u670821\u65e5<\/span>\n <\/h5>\n
\n

\u9510\u6e43\u5c14\u2122\u6280\u672f\u7684\u4f53\u5916\u8f6c\u5f55\uff08IVT\uff09RNA\u3001RNP\u5f62\u5f0f\u7533\u8bf7\u53d1\u660e\u4e13\u5229<\/p> <\/div>\n <\/div>\n <\/div>\n \t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

\u6280\u672f\u80cc\u666f\u7b80\u8ff0<\/h2>
<\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

\u8f6c\u5ea7\u5b50(Alu\u5143\u4ef6\u53caLINE-1\u7b49\uff09\u53ca\u5185\u542b\u5b50\u5360\u636e\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e0a90%\u4ee5\u4e0a\u7684\u533a\u57df\uff0c\u4f46\u76ee\u524d\u7edd\u5927\u591a\u6570\u65e0\u660e\u786e\u4f5c\u75281,2<\/SUP>\u3002<\/h2>

1.Sullivan JC, Reitzel AM, Finnerty JR. A high percentage of introns in human genes were present early in animal evolution: evidence from the basal metazoan Nematostella vectensis. Genome Inform<\/i><\/em>. 2006;17(1):219-229.<\/p>

2.Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome [published correction appears in Nature 2001 Aug 2;412(6846):565] [published correction appears in Nature 2001 Jun 7;411(6838):720. Szustakowki, J [corrected to Szustakowski, J]]. Nature<\/i><\/em>. 2001;409(6822):860-921. doi:10.1038\/35057062<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

LINE-1\u548cAlu\u5143\u4ef6\u5747\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u76ee\u524d\u4ecd\u5177\u6709\u6d3b\u6027\u7684\u8f6c\u5ea7\u5b501,2<\/SUP>\u3002LINE-1\u53ef\u8f6c\u5f55\u4ea7\u751f\u5176\u76f8\u5e94RNA\uff0c\u8868\u8fbeORF2p\u86cb\u767d\u4ee5\u52a9\u5176RNA\u9006\u8f6c\u5f55\u5e76\u63d2\u5165\uff08\u8f6c\u5ea7\uff09\u56de\u57fa\u56e0\u7ec41,2<\/SUP>\uff1bAlu\u5143\u4ef6\u5219\u4ea6\u53ef\u7531\u5176\u8f6c\u5f55\u7684RNA\u9006\u8f6c\u5f55\u5e76\u63d2\u5165\uff08\u8f6c\u5ea7\uff09\u81f3\u57fa\u56e0\u7ec4\uff0c\u4f46Alu\u5143\u4ef6\u8f6c\u5ea7\u9700LINE-1\u6240\u8868\u8fbe\u7684ORF2p\u8f85\u52a91,2<\/SUP>\u3002<\/h2>

1.Streva VA, Faber ZJ, Deininger PL. LINE-1 and Alu retrotransposition exhibit clonal variation. Mob DNA<\/i><\/em>. 2013;4(1):16. Published 2013 Jun 3. doi:10.1186\/1759-8753-4-16<\/p>

2.de Andrade A, Wang M, Bonaldo MF, Xie H, Soares MB. Genetic and epigenetic variations contributed by Alu retrotransposition. BMC Genomics<\/i><\/em>. 2011;12:617. Published 2011 Dec 20. doi:10.1186\/1471-2164-12-617<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

\u62f7\u8d1d\u6570\u53d8\u5f02\uff08copy number variation\uff0cCNV\uff09\u5728\u9996\u6b21\u4eba\u7c7b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u4e2d\u88ab\u4e25\u91cd\u4f4e\u4f301<\/SUP>\uff0c\u76f4\u81f3\u8fd1\u5e74\u624d\u88ab\u9010\u6b65\u53d1\u6398\u91cd\u89c6\u3002\u81f3\u5c11\u6709\u6570\u5343\u4e2a\u57fa\u56e0\u5177\u6709\u62f7\u8d1d\u6570\u53d8\u5f02\uff0c\u5404\u57fa\u56e0\u7684\u62f7\u8d1d\u6570\u53d8\u5f02\u5360\u636e\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684\u5927\u5757\u533a\u57df2-5<\/SUP>\u3002<\/h2>

1.Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome [published correction appears in Nature 2001 Aug 2;412(6846):565] [published correction appears in Nature 2001 Jun 7;411(6838):720. Szustakowki, J [corrected to Szustakowski, J]]. Nature<\/i><\/em>. 2001;409(6822):860-921. doi:10.1038\/35057062<\/p>

2.Iafrate AJ, Feuk L, Rivera MN, et al. Detection of large-scale variation in the human genome. Nat Genet<\/i><\/em>.2004;36(9):949-951. doi:10.1038\/ng1416<\/p>

3.Sebat J, Lakshmi B, Troge J, et al. Large-scale copy number polymorphism in the human genome. Science<\/i><\/em>. 2004;305(5683):525-528. doi:10.1126\/science.1098918<\/p>

4.Redon R, Ishikawa S, Fitch KR, et al. Global variation in copy number in the human genome. Nature<\/i><\/em>. 2006;444(7118):444-454. doi:10.1038\/nature05329<\/p>

5.Korbel JO, Urban AE, Affourtit JP, et al. Paired-end mapping reveals extensive structural variation in the human genome. Science<\/i><\/em>. 2007;318(5849):420-426. doi:10.1126\/science.1149504<\/p>

\u00a0<\/b><\/strong><\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n

\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u4ee5\u53ca\u53d1\u80b2\u7684\u80da\u80ce\u4e2d\uff0c\u53ef\u89c1\u6709\u89c4\u5f8b\u7684\u3001\u7279\u5f02\u7684\u57fa\u56e0\u7ec4\u4e0a\u62f7\u8d1d\u6570\u53d8\u5f02\u6539\u53d8\uff0c\u76ee\u524d\u8fd9\u4e9b\u6539\u53d8\u5c1a\u65e0\u660e\u786e\u4e14\u5408\u7406\u7684\u673a\u5236\u8fdb\u884c\u89e3\u91ca1-8<\/SUP>\u3002<\/h2>
  1. Vanneste E, Voet T, Le Caignec C, et al. Chromosome instability is common in human cleavage-stage embryos. Nat Med<\/i><\/em>. 2009;15(5):577-583. doi:10.1038\/nm.1924<\/li>
  2. Zhu P, Guo H, Ren Y, et al. Single-cell DNA methylome sequencing of human preimplantation embryos. Nat Genet<\/i><\/em>. 2018;50(1):12-19. doi:10.1038\/s41588-017-0007-6<\/li>
  3. Claycomb JM, Benasutti M, Bosco G, Fenger DD, Orr-Weaver TL. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Dev Cell<\/i><\/em>. 2004;6(1):145-155. doi:10.1016\/s1534-5807(03)00398-8<\/li>
  4. Fischer U, Keller A, Voss M, Backes C, Welter C, Meese E. Genome-wide gene amplification during differentiation of neural progenitor cells in vitro. PLoS One<\/i><\/em>. 2012;7(5):e37422. doi:10.1371\/journal.pone.0037422<\/li>
  5. Meinhardt G, Kaltenberger S, Fiala C, Kn\u00f6fler M, Pollheimer J. ERBB2 gene amplification increases during the transition of proximal EGFR(+) to distal HLA-G(+) first trimester cell column trophoblasts. Placenta<\/i><\/em>. 2015;36(8):803-808. doi:10.1016\/j.placenta.2015.05.017<\/li>
  6. Hannibal RL, Baker JC. Selective Amplification of the Genome Surrounding Key Placental Genes in Trophoblast Giant Cells. Curr Biol<\/i><\/em>. 2016;26(2):230-236. doi:10.1016\/j.cub.2015.11.060<\/li>
  7. Shao X, Lv N, Liao J, et al. Copy number variation is highly correlated with differential gene expression: a pan-cancer study. BMC Med Genet<\/i><\/em>. 2019;20(1):175. doi:10.1186\/s12881-019-0909-5<\/li>
  8. Henrichsen CN, Vinckenbosch N, Z\u00f6llner S, et al. Segmental copy number variation shapes tissue transcriptomes. Nat Genet<\/i><\/em>. 2009;41(4):424-429. doi:10.1038\/ng.345<\/li><\/ol><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u968f\u7740\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u53ef\u89c1\u57fa\u56e0\u7ec4\u4e0a\u5404\u57fa\u56e0\u7684\u62f7\u8d1d\u6570\u53d8\u53161<\/SUP>\u3002<\/h2>

    1.Liang Q, Conte N, Skarnes WC, Bradley A. Extensive genomic copy number variation in embryonic stem cells. Proc Natl Acad Sci U S A<\/i><\/em>. 2008;105(45):17453-17456. doi:10.1073\/pnas.0805638105<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5728\u80bf\u7624\u7ec6\u80de\u3001\u5e72\u7ec6\u80de\u4ee5\u53ca\u80da\u80ce\u4e2d\uff0c\u4ea6\u53ef\u89c1\u8f6c\u5ea7\u5b50\u5982LINE-1\u53caSINE\u7684\u53bb\u7532\u57fa\u5316\u4ee5\u53ca\u9ad8\u8868\u8fbe1-4<\/SUP>\u3002<\/h2>

    1.Martin SL. The ORF1 protein encoded by LINE-1: structure and function during L1 retrotransposition. J Biomed Biotechnol<\/i><\/em>. 2006;2006(1):45621. doi:10.1155\/JBB\/2006\/45621<\/p>

    2.Adeniyi-Jones S, Zasloff M. Transcription, processing and nuclear transport of a B1 Alu RNA species complementary to an intron of the murine alpha-fetoprotein gene. Nature<\/i><\/em>. 1985;317(6032):81-84. doi:10.1038\/317081a0<\/p>

    3.Kerachian MA, Kerachian M. Long interspersed nucleotide element-1 (LINE-1) methylation in colorectal cancer. Clin Chim Acta<\/i><\/em>. 2019;488:209-214. doi:10.1016\/j.cca.2018.11.018<\/p>

    4.Whongsiri P, Goering W, Lautwein T, et al. Many Different LINE-1 Retroelements Are Activated in Bladder Cancer. Int J Mol Sci<\/i><\/em>. 2020;21(24):9433. Published 2020 Dec 11. doi:10.3390\/ijms21249433<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5bf9LINE-1\u7684\u8868\u8fbe\u8fdb\u884c\u6291\u5236\u540e\u80da\u80ce\u53d1\u80b2\u505c\u6ede1<\/SUP>\u3002<\/h2>

    1.Percharde M, Lin CJ, Yin Y, et al. A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity. Cell<\/i><\/em>. 2018;174(2):391-405.e19. doi:10.1016\/j.cell.2018.05.043<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    HIV\u57fa\u56e0\u7ec4\u504f\u597d\u4e8e\u63d2\u5165\u81f3\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684Alu\u5143\u4ef6\uff0c\u5c24\u5176\u662f\u9ad8\u8f6c\u5f55\u6c34\u5e73\u57fa\u56e0\u4e0a\u7684Alu\u5143\u4ef6\uff1b\u6b64\u79cd\u514b\u9686\u6027\u6269\u589e\u7684\u63d2\u5165\u4ec5\u53d1\u751f\u4e8e\u5c11\u6570\u5177\u6709\u6301\u7eed\u589e\u6b96\u80fd\u529b\u7684\u7ec6\u80de\uff1b\u7edd\u5927\u591a\u6570\u88ab\u63d2\u5165\u7684HIV\u57fa\u56e0\u7ec4\u4ec5\u4e3a\u5176\u5b8c\u6574\u57fa\u56e0\u7ec4\u7684\u4e00\u90e8\u52061-3<\/SUP>\u3002<\/h2>

    1.Cohn LB, Silva IT, Oliveira TY, et al. HIV-1 integration landscape during latent and active infection. Cell<\/i><\/em>. 2015;160(3):420-432. doi:10.1016\/j.cell.2015.01.020<\/p>

    2.Maldarelli F, Wu X, Su L, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science<\/i><\/em>. 2014;345(6193):179-183. doi:10.1126\/science.1254194<\/p>

    3.Wagner TA, McLaughlin S, Garg K, et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science<\/i><\/em>. 2014;345(6196):570-573. doi:10.1126\/science.1256304<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u63a8\u5b9a\u7684HIV\u57fa\u56e0\u7ec4\u5728\u4eba\u4f53\u4e2d\u7684\u514b\u9686\u6027\u6269\u589e\u673a\u5236<\/h2>

    \u56fe\u7247\u53d6\u81eaA Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons.<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u548c\u8106\u6027X\u7efc\u5408\u75c7\u7684\u81f4\u75c5\u57fa\u56e0\u4e2d\u7684\u91cd\u590d\u4e09\u8054\u6838\u82f7\u9178\u5e8f\u5217\u7684\u6269\u589e\u4e0e\u76f8\u5e94\u57fa\u56e0\u7684\u8f6c\u5f55\u6c34\u5e73\u5448\u6b63\u76f8\u51731-4<\/SUP>\u3002<\/h2>

    1.Cohn LB, Silva IT, Oliveira TY, et al. HIV-1 integration landscape during latent and active infection. Cell<\/i><\/em>. 2015;160(3):420-432. doi:10.1016\/j.cell.2015.01.020<\/p>

    2.Maldarelli F, Wu X, Su L, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science<\/i><\/em>. 2014;345(6193):179-183. doi:10.1126\/science.1254194<\/p>

    3.Wagner TA, McLaughlin S, Garg K, et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science<\/i><\/em>. 2014;345(6196):570-573. doi:10.1126\/science.1256304<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u63a8\u5b9a\u7684\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u548c\u8106\u6027X\u7efc\u5408\u75c7\u7684\u81f4\u75c5\u57fa\u56e0\u4e2d\u7684\u91cd\u590d\u4e09\u8054\u6838\u82f7\u9178\u5e8f\u5217\u7684\u6269\u589e\u673a\u5236<\/h2>

    \u56fe\u7247\u53d6\u81eaA Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons.<\/p>

    \u00a0<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5185\u542b\u5b50\u4ea7\u751f\u7684circRNA\u53ef\u7531\u5185\u542b\u5b50\u7ecf\u526a\u63a5\u5f62\u6210\u7684\u5957\u7d22\u7ed3\u6784\u751f\u62101<\/SUP>\u3002<\/h2>

    1.Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell<\/i><\/em>. 2013;51(6):792-806. doi:10.1016\/j.molcel.2013.08.017<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5185\u542b\u5b50\u526a\u5207\u7684\u77ed\u7247\u6bb5\u7406\u8bba\uff1a\u5c06\u5177\u6709\u591a\u805aA\u5e8f\u5217\u7684\u7ebf\u6027RNA\u53bb\u9664\u540e\uff0ccircRNA\u6240\u68c0\u6d4b\u7684\u4ee5\u526a\u5207\u4f4d\u70b9\u4e3a\u8d77\u59cb\u6216\u7ec8\u6b62\u7684circRNA\uff08\u8bf4\u660e\u4e0e\u5185\u542b\u5b50\u526a\u63a5\u6709\u5173\uff09\u957f\u5ea6\u7edd\u5927\u591a\u6570<400bp\u3002\u7ecf\u526a\u63a5\u673a\u5236\u4ea7\u751f\u7684\u5957\u7d22\u7ed3\u6784\u5177\u67093'\u7aef\u6b8b\u7aef1<\/SUP>\u3002<\/h2>

    1.Panda AC, De S, Grammatikakis I, et al. High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Nucleic Acids Res<\/i><\/em>. 2017;45(12):e116. doi:10.1093\/nar\/gkx297<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5185\u542b\u5b50\u526a\u5207\u6240\u5f62\u6210\u7684\u5957\u7d22\u7ed3\u6784\u534a\u8870\u671f\u6781\u77ed\uff0c\u96be\u4ee5\u5b9e\u9645\u68c0\u6d4b1,2\u3002\u76ee\u524d\u7edd\u5927\u591a\u6570\u8ba4\u77e5\u7684\u5185\u542b\u5b50\u5f62\u6210\u7684\u5957\u7d22\u7ed3\u6784\u5747\u4e3a\u7535\u8111\u9884\u6d4b\u6216\u63a8\u6d4b\uff0c\u771f\u6b63\u4e8e\u4f53\u5185\u9a8c\u8bc1\u8fc7\u7684\u5957\u7d22\u7ed3\u6784\u4e0d\u8d85\u8fc7100\u4e2a3<\/SUP>\u3002<\/h2>

    1.Burnette JM, Miyamoto-Sato E, Schaub MA, Conklin J, Lopez AJ. Subdivision of large introns in Drosophila by recursive splicing at nonexonic elements. Genetics<\/i><\/em>. 2005;170(2):661-674. doi:10.1534\/genetics.104.039701<\/p>

    2.Kelly S, Georgomanolis T, Zirkel A, et al. Splicing of many human genes involves sites embedded within introns. Nucleic Acids Res<\/i><\/em>. 2015;43(9):4721-4732. doi:10.1093\/nar\/gkv386<\/p>

    3.Taggart AJ, DeSimone AM, Shih JS, Filloux ME, Fairbrother WG. Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo. Nat Struct Mol Biol<\/i><\/em>. 2012;19(7):719-721. Published 2012 Jun 17. doi:10.1038\/nsmb.2327<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u9009\u62e9\u6027\u526a\u5207\u5b58\u5728\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u8d8590%\u7684\u57fa\u56e0\u4e2d1-2<\/SUP>\u3002<\/h2>

    1.Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing [published correction appears in Nat Genet. 2009 Jun;41(6):762]. Nat Genet<\/i><\/em>. 2008;40(12):1413-1415. doi:10.1038\/ng.259<\/p>

    2.Wang ET, Sandberg R, Luo S, et al. Alternative isoform regulation in human tissue transcriptomes. Nature<\/i><\/em>. 2008;456(7221):470-476. doi:10.1038\/nature07509<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u53bb\u9664\u53c2\u4e0e\u5185\u542b\u5b50\u526a\u5207\u7684\u526a\u5207\u56e0\u5b50ASF\/SF2\u540e\uff0c\u771f\u6838\u7ec6\u80de\u57fa\u56e0\u7ec4\u51fa\u73b0\u660e\u663e\u4e0d\u7a33\u5b9a\u5e76\u51fa\u73b0\u67d3\u8272\u4f53\u5916\u7684\u9ad8\u5206\u5b50\u957fDNA\u7247\u6bb51<\/SUP>\u3002<\/h2>

    1.Li X, Manley JL. Inactivation of the SR protein splicing factor ASF\/SF2 results in genomic instability. Cell<\/i><\/em>. 2005;122(3):365-378. doi:10.1016\/j.cell.2005.06.008<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u63a8\u5b9a\u7684\u5185\u542b\u5b50\u526a\u5207\u673a\u5236\uff1a<\/h2>

    \u56fe\u7247\u53d6\u81eaA Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons.<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u6709\u89c4\u5f8b\u7684\u77edRNA\u8f6c\u5316\u4e3a\u53cc\u94feDNA\uff1a\u4eba\u7c7b\u7ec6\u80de\u4e2d\u666e\u904d\u5b58\u5728\u4e00\u79cd\u7edd\u5927\u591a\u6570\u957f\u5ea6<400bp\u7684\u53cc\u94fe\u6216\u5355\u94feDNA\uff0c\u5176\u4ea7\u751f\u4e0e\u5176\u76f8\u5e94\u57fa\u56e0\u5e8f\u5217\u7684\u8f6c\u5f55\u53ca\u526a\u5207\u9ad8\u5ea6\u76f8\u51731,2<\/SUP>\u3002\u6b64\u5916\uff0c\u5f88\u5927\u4e00\u90e8\u5206\u7684\u8be5\u77ed\u5e8f\u5217DNA\u542b\u6709\u77ed\u6563\u5728\u6838\u5143\u4ef6\u5982Alu\u5143\u4ef6\u5e8f\u5217\u6216Alu\u5143\u4ef6\u5bcc\u542b\u7684CpG\u5c9b2<\/SUP>\u3002<\/h2>

    1.Shibata Y, Kumar P, Layer R, et al. Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues [published correction appears in Science. 2012 Jun 22;336(6088):1506]. Science<\/i><\/em>. 2012;336(6077):82-86. doi:10.1126\/science.1213307<\/p>

    2.Dillon LW, Kumar P, Shibata Y, et al. Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity. Cell Rep<\/i><\/em>. 2015;11(11):1749-1759. doi:10.1016\/j.celrep.2015.05.020<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u7cbe\u5b50\u4e2d\u72ec\u7acb\u4e8e\u57fa\u56e0\u7ec4\u7684DNA\u7247\u6bb5\u88ab\u79f0\u505a\u7cbe\u5b50DNA\u7247\u6bb5\uff08sperm DNA fragmentation \uff0cSDF)\uff0c\u8be5\u7247\u6bb5\u666e\u904d\u5b58\u5728\u4e8e\u6b63\u5e38\u7684\u7cbe\u5b50\u4e2d1<\/SUP>\u3002<\/h2>

    1.Evenson DP, Darzynkiewicz Z, Melamed MR. Relation of mammalian sperm chromatin heterogeneity to fertility. Science<\/i><\/em>. 1980;210(4474):1131-1133. doi:10.1126\/science.7444440<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    Alu\u5143\u4ef6\u8f6c\u5f55\u4ea7\u751f\u7684RNA\u5728\u7ec6\u80de\u6838\u5185\u4e8e\u5176\u5e8f\u5217\u4e0a\u7684\u56fa\u5b9a\u4f4d\u70b9\u88ab\u526a\u5207\u4e3a5'<\/SUP>\u90e8\u5206\u548c3'\u90e8\u5206\uff0c5'<\/SUP>\u90e8\u5206\u534a\u8870\u671f\u8f83\u957f\u800c\u65e0\u660e\u663e\u529f\u80fd\uff0c3'<\/SUP>\u90e8\u5206\u5219\u8fc5\u901f\u6d88\u5931\u96be\u4ee5\u68c0\u6d4b\uff0c\u63d0\u793a\u5176\u53e6\u6709\u529f\u80fd\u30023'<\/SUP>\u90e8\u5206\u7559\u67095'\u7aef\u6b8b\u7aef1,2<\/SUP>\u3002<\/h2>

    1.Maraia RJ, Driscoll CT, Bilyeu T, Hsu K, Darlington GJ. Multiple dispersed loci produce small cytoplasmic Alu RNA. Mol Cell Biol<\/i><\/em>. 1993;13(7):4233-4241. doi:10.1128\/mcb.13.7.4233-4241.1993<\/p>

    2.Chu WM, Liu WM, Schmid CW. RNA polymerase III promoter and terminator elements affect Alu RNA expression. Nucleic Acids Res<\/i><\/em>. 1995;23(10):1750-1757. doi:10.1093\/nar\/23.10.1750<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    Alu\u5143\u4ef6\u8f6c\u5f55\u4ea7\u751f\u7684RNA\u4e8e\u6838\u5185\u526a\u5207\u4ea7\u751f\u76843'<\/SUP>\u90e8\u5206\u53ef\u7ed3\u5408\u4eba\u6e90\u7684\u5185\u5207\u9176\u53ca\u9006\u8f6c\u5f55\u9176ORF2p\uff0cORF2p\u53ef\u5207\u5f00\u57fa\u56e0\u7ec4\u5355\u94fe\uff0c\u5f15\u53d1\u9006\u8f6c\u5f55\u5e76\u4ecb\u5bfc\u8f6c\u5ea7\uff1b\u6b64\u524d\u5c1a\u672a\u6709\u7406\u8bba\u7ed9\u51faORF2p\u5c06Alu-RNA\u7b2c\u4e8c\u6761\u94fe\u63d2\u5165\u81f3\u57fa\u56e0\u7ec4\u7684\u5408\u7406\u89e3\u91ca1,2<\/SUP>\u3002<\/h2>

    1.Mathias SL, Scott AF, Kazazian HH Jr, Boeke JD, Gabriel A. Reverse transcriptase encoded by a human transposable element. Science<\/i><\/em>. 1991;254(5039):1808-1810. doi:10.1126\/science.1722352<\/p>

    2.Wallace N, Wagstaff BJ, Deininger PL, Roy-Engel AM. LINE-1 ORF1 protein enhances Alu SINE retrotransposition. Gene<\/i><\/em>. 2008;419(1-2):1-6. doi:10.1016\/j.gene.2008.04.007<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    Alu-RNA\u7ed3\u5408ORF2p\u4e8e\u57fa\u56e0\u7ec4\u4e0a\u6240\u4f5c\u7528\u7684\u526a\u5207\u5e8f\u5217\u7edd\u5927\u591a\u6570\u4e3a5-TTTT\/AA-3\uff08\u201c\/\u201d\u4ee3\u8868\u526a\u5207\u4f4d\u70b9\uff09\uff0c\u57fa\u56e0\u7ec4\u4e0a\u526a\u5207\u5e8f\u5217\u4e8eAlu-RNA\u4e0a\u6240\u5bf9\u5e94\u5e8f\u5217\u7684\u4e8c\u7ea7\u7ed3\u6784\u5448\u201c\u03a9\u201d\u578b\uff0c\u201c\u03a9\u201d\u7684\u7f3a\u53e3\u6b63\u5bf9\u526a\u5207\u4f4d\u70b91-3<\/SUP>\u3002<\/h2>

    1.Mathias SL, Scott AF, Kazazian HH Jr, Boeke JD, Gabriel A. Reverse transcriptase encoded by a human transposable element. Science<\/i><\/em>. 1991;254(5039):1808-1810. doi:10.1126\/science.1722352<\/p>

    2.Wallace N, Wagstaff BJ, Deininger PL, Roy-Engel AM. LINE-1 ORF1 protein enhances Alu SINE retrotransposition. Gene<\/i><\/em>. 2008;419(1-2):1-6. doi:10.1016\/j.gene.2008.04.007<\/p>

    3.H\u00e4sler J, Strub K. Alu elements as regulators of gene expression [published correction appears in Nucleic Acids Res. 2007;35(4):1389]. Nucleic Acids Res<\/i><\/em>. 2006;34(19):5491-5497. doi:10.1093\/nar\/gkl706<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u5728\u4eba\u4f53\u4e2d\uff0c\u8f6c\u5ea7\u5b50\u5982LINE-1\u53ef\u7f16\u7801\u9006\u8f6c\u5f55\u9176ORF2p\uff0c\u5bf9RNA\u8fdb\u884c\u9006\u8f6c\u5f55\u3002\u5728LINE-1\u7684\u5e2e\u52a9\u4e0b\uff0c\u4efb\u4f55mRNA\u5747\u53ef\u88ab\u9006\u8f6c\u5f55\u5e76\u88ab\u63d2\u5165\uff08\u8f6c\u5ea7\uff09\u81f3\u57fa\u56e0\u7ec4\u4e2d1,2<\/SUP>\u3002<\/h2>

    1.Esnault C, Maestre J, Heidmann T. Human LINE retrotransposons generate processed pseudogenes. Nat Genet<\/i><\/em>. 2000;24(4):363-367. doi:10.1038\/74184<\/p>

    2.Dewannieux M, Esnault C, Heidmann T. LINE-mediated retrotransposition of marked Alu sequences. Nat Genet<\/i><\/em>. 2003;35(1):41-48. doi:10.1038\/ng1223<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u8f6c\u5f55\u76f8\u5173\u7684\u540c\u6e90\u91cd\u7ec4\u666e\u904d\u5b58\u5728\u4e8e\u54fa\u4e73\u52a8\u7269\u4f53\u5185\uff0c\u5e76\u53ef\u5f15\u8d77\u57fa\u56e0\u7ec4\u6539\u53d81<\/SUP>\u3002<\/h2>

    1.Gottipati P, Cassel TN, Savolainen L, Helleday T. Transcription-associated recombination is dependent on replication in Mammalian cells. Mol Cell Biol<\/i><\/em>. 2008;28(1):154-164. doi:10.1128\/MCB.00816-07<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u7ec6\u83cc\u4e2d\u7684II\u578b\u5185\u542b\u5b50\u7684\u8f6c\u5ea7\u529f\u80fd\u4f9d\u8d56\u4e8e\u5176\u5957\u7d22\u7ed3\u6784+\u5185\u5207\u9176+\u9006\u8f6c\u5f55\u9176\uff08\u76ee\u524dTargetron\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4fbf\u57fa\u4e8e\u6b64\uff091-4<\/SUP>\u3002<\/h2>

    1.Guo H, Karberg M, Long M, Jones JP 3rd, Sullenger B, Lambowitz AM. Group II introns designed to insert into therapeutically relevant DNA target sites in human cells. Science<\/i><\/em>. 2000;289(5478):452-457. doi:10.1126\/science.289.5478.452<\/p>

    2.Guo H, Zimmerly S, Perlman PS, Lambowitz AM. Group II intron endonucleases use both RNA and protein subunits for recognition of specific sequences in double-stranded DNA. EMBO J<\/i><\/em>. 1997;16(22):6835-6848. doi:10.1093\/emboj\/16.22.6835<\/p>

    3.Jim\u00e9nez-Zurdo JI, Garc\u00eda-Rodr\u00edguez FM, Barrientos-Dur\u00e1n A, Toro N. DNA target site requirements for homing in vivo of a bacterial group II intron encoding a protein lacking the DNA endonuclease domain. J Mol Biol<\/i><\/em>. 2003;326(2):413-423. doi:10.1016\/s0022-2836(02)01380-3<\/p>

    4.Singh NN, Lambowitz AM. Interaction of a group II intron ribonucleoprotein endonuclease with its DNA target site investigated by DNA footprinting and modification interference. J Mol Biol<\/i><\/em>. 2001;309(2):361-386. doi:10.1006\/jmbi.2001.4658<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    II\u578b\u5185\u542b\u5b50\u53ef\u9996\u5148\u7531RNA\u8f6c\u5316\u4e3adsDNA\u540e\u57fa\u4e8e\u540c\u6e90\u91cd\u7ec4\u8fdb\u884c\u8f6c\u5ea7\u5f52\u5de21<\/SUP>\u3002<\/h2>

    1.Cousineau B, Lawrence S, Smith D, Belfort M. Retrotransposition of a bacterial group II intron [published correction appears in Nature 2001 Nov 1;414(6859):84]. Nature<\/i><\/em>. 2000;404(6781):1018-1021. doi:10.1038\/35010029<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u4eba\u4f53\u5185\u5df2\u6709RNA\u7ecf\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u9176\u9006\u8f6c\u5f55\u4e3a\u53cc\u94feDNA\uff0c\u5e76\u968f\u7ec6\u80de\u5206\u88c2\u901a\u8fc7\u540c\u6e90\u91cd\u7ec4\u5b9a\u5411\u4e14\u7279\u5f02\u7684\u63d2\u5165\u81f3\u57fa\u56e0\u7ec4\u7684\u5148\u4f8b\uff0c\u5373\u7aef\u7c92\u9176\u5ef6\u957f\u7aef\u7c92\u7684\u76f8\u5173\u673a\u52361,2<\/SUP>\u3002\u6b64\u5916\uff0c\u5728\u67d0\u4e9b\u7f3a\u5931\u7aef\u7c92\u9176\u7684\u7269\u79cd\u4e2d\uff0c\u8f6c\u5ea7\u5b50\u4e5f\u53ef\u66ff\u4ee3\u7aef\u7c92\u9176\u8fdb\u884c\u7aef\u7c92\u7684\u5ef6\u957f3,4<\/SUP>\u3002<\/h2>

    1.Shampay J, Blackburn EH. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A<\/i><\/em>. 1988;85(2):534-538. doi:10.1073\/pnas.85.2.534<\/p>

    2.Sobinoff AP, Pickett HA. Mechanisms that drive telomere maintenance and recombination in human cancers. Curr Opin Genet Dev<\/i><\/em>. 2020;60:25-30. doi:10.1016\/j.gde.2020.02.006<\/p>

    3.Danilevskaya ON, Arkhipova IR, Traverse KL, Pardue ML. Promoting in tandem: the promoter for telomere transposon HeT-A and implications for the evolution of retroviral LTRs. Cell<\/i><\/em>. 1997;88(5):647-655. doi:10.1016\/s0092-8674(00)81907-8<\/p>

    4.Villasante A, de Pablos B, M\u00e9ndez-Lago M, Abad JP. Telomere maintenance in Drosophila: rapid transposon evolution at chromosome ends. Cell Cycle<\/i><\/em>. 2008;7(14):2134-2138. doi:10.4161\/cc.7.14.6275<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u9510\u6e43\u5c14\u00ae\u6240\u57fa\u4e8e\u7684CNV\u5ef6\u4f38\u673a\u5236\u4e0e\u7aef\u7c92\u9176\u5ef6\u4f38\u7aef\u7c92\u7684\u76f8\u5173\u673a\u5236\u5747\u662f\u901a\u8fc7\u7ec6\u80de\u5185\u7684\u5185\u6e90\u6027\u9006\u8f6c\u5f55\u9176\u9006\u8f6c\u5f55\u6838\u5185\u8f6c\u5f55\u7684RNA\u4e3a\u53cc\u94feDNA\u5e76\u5b9a\u5411\u63d2\u5165\u81f3\u57fa\u56e0\u7ec4\u7684\u7279\u5b9a\u533a\u57df\u90fd\u662f\u901a\u8fc7\u7ec6\u80de\u5206\u88c2\u6765\u9650\u5236\u7531\u5176\u76f8\u5e94\u673a\u5236\u4ecb\u5bfc\u7684\u57fa\u56e0\u7ec4\u6539\u53d8\u3002<\/h2><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    \u9510\u6e43\u5c14\u00ae\u6280\u672f\u6240\u57fa\u4e8e\u7684CNV\u5ef6\u4f38\u673a\u5236\u4e0eII\u578b\u5185\u542b\u5b50\u7684\u8f6c\u5ea7\u673a\u5236\u5219\u5747\u662f\u5148\u4f7f\u5185\u542b\u5b50RNA\u901a\u8fc7\u7279\u6b8a\u7684\u4e8c\u7ea7\u7ed3\u6784\u5f62\u6210\u5957\u7d22\u7ed3\u6784\uff0c\u6b64\u540e\u901a\u8fc7\u7ed3\u5408\u4e8e\u5957\u7d22\u7ed3\u6784\u7684\u5185\u5207\u9176\u5207\u5f00\u57fa\u56e0\u7ec4\u540c\u65f6\u5c06RNA\u9006\u8f6c\u5f55\u4e3a\u53cc\u94feDNA\uff0c\u6700\u7ec8\u901a\u8fc7\u53cc\u94feDNA\u4e0e\u57fa\u56e0\u7ec4\u7ed3\u5408\u5f62\u6210\u201c\u03a9\u201d\u578b\u7ed3\u6784\u5e76\u901a\u8fc7\u540c\u6e90\u91cd\u7ec4\u63d2\u5165\u81f3\u57fa\u56e0\u7ec4\u3002<\/h2><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t
    \n

    II\u578b\u5185\u542b\u5b50\u4e0e\u9510\u6e43\u5c14\u00ae\u6280\u672f\u6bd4\u8f83<\/h2>

    \u56fe\u7247\u53d6\u81eaA Mechanism Leading to Changes in Copy Number Variations Affected by Transcriptional Level Might Be Involved in Evolution, Embryonic Development, Senescence, and Oncogenesis Mediated by Retrotransposons.<\/p><\/div><\/div>\n <\/section>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t
    \n\n\t\t\t\t\t\t
    \n\t\t\t\t\n\t\t\t\t<\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t
    \n\n\t\t\t\t\t\t\t\t\t

    \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\u66f4\u591a\u6280\u672f\u7ec6\u8282\u6b22\u8fce\u6765\u7535\u6216\u5728\u7ebf\u54a8\u8be2\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t
    \n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\u8054\u7cfb\u6211\u4eec >>><\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t <\/div>\r\n <\/div>\r\n
    \r\n
    \r\n \t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    \u521b\u65b0\u6027\u57fa\u56e0\u7f16\u8f91\u8f85\u52a9\u6280\u672f\u2014\u523b\u6bcb\u9650\u00ae<\/sup><\/span><\/span><\/strong><\/span>
    \uff08Copifinite<\/span>\u00ae<\/sup><\/span><\/span><\/strong><\/span>\uff09 <\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    \u523b\u6bcb\u9650<\/strong>\u00ae<\/sup><\/span><\/span><\/strong><\/span><\/p>

    \u6280\u672f\u5e94\u7528Alu\u5143\u4ef6\u7b49\u4eba\u6e90\u9006\u8f6c\u5ea7\u5b50\uff0c\u7ed3\u5408\u4eba\u6e90\u7684\u9006\u8f6c\u5f55\u9176ORF2p\uff0c\u4f7f\u7531DNA\u8f7d\u4f53\u8f6c\u5f55\u4ea7\u751f\u7684\u542b\u6709\u9776\u4f4d\u70b9\uff08\u9776\u4f4d\u70b9\u4e0a\u6e38\u5e8f\u5217\u548c\u9776\u4f4d\u70b9\u4e0b\u6e38\u5e8f\u5217\uff09\u53ca\u5f85\u63d2\u5165\u5e8f\u5217\u4fe1\u606f\u7684\u7279\u5b9aRNA\u88ab\u4e0d\u65ad\u9006\u8f6c\u5f55\u4e3aDNA\uff0c\u4e3aTALEN\u3001ZFN\u6216CRISPR-Cas9\u7b49\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5728\u5207\u5f00\u57fa\u56e0\u7ec4\u540e\u63d0\u4f9b\u5145\u8db3\u7684\u540c\u6e90\u91cd\u7ec4\u6a21\u677f\uff0c\u4ece\u800c\u63d0\u9ad8\u57fa\u56e0\u7f16\u8f91\u7684\u6548\u7387\u3002<\/p>

    \u523b\u6bcb\u9650<\/strong>\u00ae<\/sup><\/span><\/span><\/strong><\/span><\/p>

    \u6280\u672f\u540c\u6837\u53ef\u4ee5\u5728\u4f53\u5916\u5236\u5907RNA\u6216\u4e8e\u4f53\u5916\u4f7fRNA\u7ed3\u5408ORF2p\u7b49\u86cb\u767d\u5f62\u6210RNP\u540e\u518d\u7ed9\u4e88\u76ee\u6807\u4f53\u7cfb\u53d1\u6325\u4f5c\u7528\uff0c\u4f7fCRISPR-Cas9\u6280\u672f\u5f7b\u5e95\u8131\u79bbDNA\u6210\u5206\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t

    \u523b\u6bcb\u9650\u6280\u672f\u539f\u7406\u793a\u610f\u56fe<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"16-img\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\u5fae\u4fe1\u56fe\u7247\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t <\/div>\r\n <\/div>\r\n <\/div>\r\n<\/div>\r\n \r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    \u6280\u672f\u539f\u7406 \/ Technical Principles \u9510\u6e43\u5c14 \u523b\u6bcb\u9650 \u521b\u65b0\u6027\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u2014\u9510\u6e43\u5c14\u2122 \uff08REP […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2233","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/pages\/2233","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2233"}],"version-history":[{"count":21,"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/pages\/2233\/revisions"}],"predecessor-version":[{"id":4785,"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=\/wp\/v2\/pages\/2233\/revisions\/4785"}],"wp:attachment":[{"href":"https:\/\/www.hongyunqingxiao.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}